Anyone can develop a ‘tolerance’ to hallucinogens with regular and/or heavy use. The term “tolerance” means that you must take more of the drug to feel the same effects that you used to have with smaller amounts. Tolerance has been reported to develop rapidly to the euphoria and psychedelic effects of the hallucinogens, but not to the autonomic effects such as pupillary dilation, hyperreflexia, increased body temperature, piloerection and tachycardia. Cross-Tolerance exists between LSD and other hallucinogens. Cross-Tolerance is a condition in which developing tolerance to one kind of hallucinogen can also make you tolerant to other kinds.
According to the Diagnostic and Statistical Manual of Mental Disorders – Fourth Edition, “some of the generic criteria for substance dependence do not apply to hallucinogens. Hallucinogen use, even among those who meet the full criteria for dependence, is often limited to only a few times per week, and may be an attempt to suppress the development of tolerance to the psychological effects of the hallucinogens. Withdrawal has not been demonstrated, but clear report of ‘craving’ after stopping hallucinogens are known.”
